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1

The syntheses and in vitro biotransformation studies of [14C]apixaban, a highly potent, selective, efficacious and orally bioavailable inhibitor of blood coagulation Factor Xa

Brad D. Maxwell, Scott B. Tran, Shiang-Yuan Chen, Donglu Zhang, Bang-Chi Chen, Huiping Zhang, Samuel J. Bonacorsi Jr

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2011

Langue:

english

Fichier:

PDF, 223 KB

english, 2011

2

A new synthesis of the anti-AIDS drug AZT from 5-methyluridine

Bang-Chi Chen, Sandra L. Quinlan, J. Gregory Reid

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 203 KB

english, 1995

3

Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors

Karnail S. Atwal, Steven V. O’Neil, Saleem Ahmad, Lidia Doweyko, Mark Kirby, Charles R. Dorso, Gamini Chandrasena, Bang-Chi Chen, Rulin Zhao, Robert Zahler

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 120 KB

english, 2006

4

Reaction of quinoxalin-2-ones with TosMIC reagent: synthesis of imidazo[1,5-a]quinoxalin-4-ones

Ping Chen, Joel C. Barrish, Edwin Iwanowicz, James Lin, Mark S. Bednarz, Bang-Chi Chen

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 63 KB

english, 2001

5

Vicarious nucleophilic substitution of 1-benzyl-5-nitroimidazole, application to the synthesis of 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one

Bang-Chi Chen, Sam T. Chao, Joseph E. Sundeen, John Tellew, Saleem Ahmad

Journal:

Tetrahedron Letters

Année:

2002

Langue:

english

Fichier:

PDF, 53 KB

english, 2002

6

A new highly enantioselective synthesis of both (R)- and (S)-2-mercaptosuccinic acids

Bang-Chi Chen, Mark S Bednarz, Octavian R Kocy, Joseph E Sundeen

Journal:

Tetrahedron: Asymmetry

Année:

1998

Langue:

english

Fichier:

PDF, 111 KB

english, 1998

7

Nucleophilic Aromatic Substitution of Methacrylamide Anion and Its Application to the Synthesis of the Anticancer Drug Bicalutamide

Chen, Bang-Chi, Zhao, Rulin, Gove, Stacey, Wang, Bei, Sundeen, Joseph E., Salvati, Mark E., Barrish, Joel C.

Journal:

Journal of Organic Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 38 KB

english, 2003

8

Organic Reactions || ��-Hydroxylation of Enolates and Silyl Enol Ethers

Année:

2004

Fichier:

PDF, 3.43 MB

2004

9

Quantitation of the acid and lactone forms of atorvastatin and its biotransformation products in human serum by high-performance liquid chromatography with electrospray tandem mass spectrometry

Mohammed Jemal, Zheng Ouyang, Bang-Chi Chen, Deborah Teitz

Journal:

Rapid Communications in Mass Spectrometry

Année:

1999

Langue:

english

Fichier:

PDF, 203 KB

english, 1999

10

Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum

Bang-Chi Chen, Joseph E. Sundeen, Peng Guo, Mark S. Bednarz, Jon J. Hangeland, Syed Z. Ahmed, Mohammed Jemal

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2000

Fichier:

PDF, 281 KB

2000

11

ChemInform Abstract: A Facile Method for the Transformation of N-(tert-Butoxycarbonyl) α-Amino Acids to N-Unprotected α-Amino Methyl Esters.

Bang-Chi Chen, Amanda P. Skoumbourdies, Peng Guo, Mark S. Bednarz, Octavian R. Kocy, Joseph E. Sundeen, Gregory D. Vite

Journal:

Année:

2000

Fichier:

PDF, 34 KB

2000

12

ChemInform Abstract: A New Facile Method for the Synthesis of 1-Arylimidazole-5-carboxylates.

Bang-Chi Chen, Mark S. Bednarz, Rulin Zhao, Joseph E. Sundeen, Ping Chen, Zhongqi Shen, Amanda P. Skoumbourdis, Joel C. Barrish

Journal:

Année:

2000

Fichier:

PDF, 32 KB

2000

13

ChemInform Abstract: Efficient Molar-Scale Synthesis of 1-Methyl-5-acylimidazole Triflic Acid Salts.

Bang-Chi Chen, Amanda P. Skoumbourdis, Joseph E. Sundeen, George C. Rovnyak, Sarah C. Traeger

Journal:

Année:

2001

Fichier:

PDF, 28 KB

2001

14

ChemInform Abstract: Novel Triethylsilane Mediated Reductive N-Alkylation of Amines: Improved Synthesis of 1-(4-Imidazolyl)methyl-4-sulfonylbenzodiazepines, New Farnesyltransferase Inhibitors.

Bang-Chi Chen, Joseph E. Sundeen, Peng Guo, Mark S. Bednarz, Rulin Zhao

Journal:

Année:

2001

Fichier:

PDF, 28 KB

2001

15

ChemInform Abstract: A New Facile Synthesis of 2-Aminothiazole-5-carboxylates.

Rulin Zhao, Stacey Gove, Joseph E. Sundeen, Bang-Chi Chen

Journal:

Année:

2001

Fichier:

PDF, 29 KB

2001

16

ChemInform Abstract: A General Large Scale Synthesis of 2-Alkyl-7-methoxyindoles.

Bang-Chi Chen, John Hynes Jr., Chennagiri R. Pandit, Rulin Zhao, Amanda P. Skoumbourdis, Hong Wu, Joseph E. Sundeen, Katerina Leftheris

Journal:

Année:

2001

Fichier:

PDF, 30 KB

2001

17

ChemInform Abstract: Synthesis of Imidazo[1,5-a]quinoxalin-4(5H)-one Template via a Novel Intramolecular Cyclization Process.

Derek Norris, Ping Chen, Joel C. Barrish, Jagabandhu Das, Robert Moquin, Bang-Chi Chen, Peng Guo

Journal:

Année:

2001

Fichier:

PDF, 32 KB

2001

18

ChemInform Abstract: Reaction of Quinoxalin-2-ones with TosMIC Reagent: Synthesis of Imidazo[1,5-a]quinoxalin-4-ones.

Ping Chen, Joel C. Barrish, Edwin Iwanowicz, James Lin, Mark S. Bednarz, Bang-Chi Chen

Journal:

Année:

2001

Fichier:

PDF, 30 KB

2001

19

ChemInform Abstract: A New Facile Method for the Stereoselective Synthesis of trans-2-Aryl-3,3-dimethylcyclopropane-1-carboxylic Acids.

Bang-Chi Chen, Khehyong Ngu, Peng Guo, Wen Liu, Joseph E. Sundeen, David S. Weinstein, Karnail S. Atwal, Saleem Ahmad

Journal:

Année:

2001

Fichier:

PDF, 32 KB

2001

20

A Modified Approach to 2-(N-Aryl)-1,3-oxazoles: Application to the Synthesis of the IMPDH Inhibitor BMS-337197 and Analogues.

T. G. Murali Dhar, Junqing Guo, Zhongqi Shen, William J. Pitts, Henry H. Gu, Bang-Chi Chen, Rulin Zhao, Mark S. Bednarz, Edwin J. Iwanowicz

Journal:

Année:

2002

Fichier:

PDF, 37 KB

2002

21

Nucleophilic Aromatic Substitution of Methacrylamide Anion and Its Application to the Synthesis of the Anticancer Drug Bicalutamide.

Bang-Chi Chen, Rulin Zhao, Stacey Gove, Bei Wang, Joseph E. Sundeen, Mark E. Salvati, Joel C. Barrish

Journal:

Année:

2004

Fichier:

PDF, 93 KB

2004

22

Recent Advances in Asymmetric Reactions Using Sulfinimines (N-Sulfinyl Imines)

Ping Zhou, Bang-Chi Chen, Franklin A. Davis

Journal:

Année:

2004

Fichier:

PDF, 7 KB

2004

23

α-Hydroxylation of Enolates and Silyl Enol Ethers

Bang-Chi Chen, Ping Zhou, Franklin A. Davis, Engelbert Ciganek

Journal:

Année:

2005

Fichier:

PDF, 8 KB

2005

24

ChemInform Abstract: Preparation of Monofluorophenols via the Reaction of Difluorobenzene Derivatives with Potassium Trimethylsilanoate.

Jianqing Li, Daniel Smith, Jennifer X. Qiao, Stella Huang, Subramaniam Krishnananthan, Henry S. Wong, Mark E. Salvati, Balu N. Balasubramanian, Bang-Chi Chen

Journal:

Année:

2009

Fichier:

PDF, 27 KB

2009

25

Synthesis of d3-cerivastatin for use as internal standard in a LC/MS/MS method developed for quantitation of the drug in human serum

Bang-Chi Chen, Mark S. Bednarz, Huiping Zhang, Peng Guo, Mohammed Jemal, Jeffrey A. Robl, Scott A. Biller, Joseph E. Sundeen, Balu Balasubramanian, Joel C. Barrish

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2006

Langue:

english

Fichier:

PDF, 111 KB

english, 2006

26

Synthesis of 14C-labeled and 13C-,15N-labeled dasatinib and its piperazine N-dealkyl metabolite

Alban J. Allentoff, Michael W. Lago, Marc Ogan, Bang-Chi Chen, Rulin Zhao, Ramaswarmy A. Iyer, Lisa J. Christopher, J. Kent Rinehart, Balu Balasubramanian, Samuel J. Bonacorsi Jr

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2008

Langue:

english

Fichier:

PDF, 186 KB

english, 2008

27

5′-Benzoyl-2′α-bromo-3′-O-methanesulfonylthymidine: A superior nucleoside for the synthesis of the anti-AIDS drug D4T (Stavudine)

Bang-Chi Chen, Sandra L. Quinlan, Derron R. Stark, J. Gregory Reid, Vicki H. Audia, Jacqueline G. George, Emerich Eisenreich, Steve P. Brundidge, Saibaba Racha, Richard H. Spector

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 249 KB

english, 1995

28

Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1

Saleem Ahmad, Khehyong Ngu, Donald W Combs, Shung C Wu, David S Weinstein, Wen Liu, Bang-Chi Chen, Gamini Chandrasena, Charles R Dorso, Mark Kirby, Karnail S Atwal

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 177 KB

english, 2004

29

Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56Lck inhibitors

Ping Chen, Derek Norris, Jagabandhu Das, Steven H. Spergel, John Wityak, Leslie Leith, Rulin Zhao, Bang-Chi Chen, Sidney Pitt, Suhong Pang, Ding Ren Shen, Rosemary Zhang, Henry F. De Fex, Arthur M. Do

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 352 KB

english, 2004

30

Recent advances in asymmetric reactions using sulfinimines (N-sulfinyl imines)

Ping Zhou, Bang-Chi Chen, Franklin A. Davis

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 2.78 MB

english, 2004

31

A practical synthesis of aryl tetrafluoroethyl ethers via the improved reaction of phenols with 1,2-dibromotetrafluoroethane

Jianqing Li, Jennifer X. Qiao, Daniel Smith, Bang-Chi Chen, Mark E. Salvati, Jacques Y. Roberge, Balu N. Balasubramanian

Journal:

Tetrahedron Letters

Année:

2007

Langue:

english

Fichier:

PDF, 124 KB

english, 2007

32

Enantioselective synthesis of (+)-kjellmanianone

Bang-Chi Chen, Michael C. Weismiller, Franklin A. Davis, Diane Boschelli, James R. Empfield, Amos B. Smith III

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 870 KB

english, 1991

33

A new facile method for the synthesis of 1-arylimidazole-5-carboxylates

Bang-Chi Chen, Mark S Bednarz, Rulin Zhao, Joseph E Sundeen, Ping Chen, Zhongqi Shen, Amanda P Skoumbourdis, Joel C Barrish

Journal:

Tetrahedron Letters

Année:

2000

Langue:

english

Fichier:

PDF, 139 KB

english, 2000

34

Novel triethylsilane mediated reductive N-alkylation of amines: improved synthesis of 1-(4-imidazolyl)methyl-4-sulfonylbenzodiazepines, new farnesyltransferase inhibitors

Bang-Chi Chen, Joseph E Sundeen, Peng Guo, Mark S Bednarz, Rulin Zhao

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 53 KB

english, 2001

35

A highly enantioselective synthesis of (R)- and (S)-5,7-odimethyleucomol

Franklin A. Davis, Bang-Chi Chen

Journal:

Tetrahedron Letters

Année:

1990

Fichier:

PDF, 177 KB

1990

36

A new facile synthesis of 2-aminothiazole-5-carboxylates

Rulin Zhao, Stacey Gove, Joseph E Sundeen, Bang-Chi Chen

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 47 KB

english, 2001

37

Synthesis of imidazo[1,5-a]quinoxalin-4(5H)-one template via a novel intramolecular cyclization process

Derek Norris, Ping Chen, Joel C Barrish, Jagabandhu Das, Robert Moquin, Bang-Chi Chen, Peng Guo

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 88 KB

english, 2001

38

A new facile method for the stereoselective synthesis of trans-2-aryl-3,3-dimethylcyclopropane-1-carboxylic acids

Bang-Chi Chen, Khehyong Ngu, Peng Guo, Wen Liu, Joseph E Sundeen, David S Weinstein, Karnail S Atwal, Saleem Ahmad

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 53 KB

english, 2001

39

A new thymine free synthesis of the anti-AIDS drug d4T via regio/stereo controlled β-elimination of bromoacetates

Bang-Chi Chen, Sandra L. Quinlan, J. Gregory Reid, Richard H. Spector

Journal:

Tetrahedron Letters

Année:

1998

Langue:

english

Fichier:

PDF, 192 KB

english, 1998

40

Quantitation of cerivastatin and its seven acid and lactone biotransformation products in human serum by liquid chromatography–electrospray tandem mass spectrometry

Mohammed Jemal, Satish Rao, Iffaaz Salahudeen, Bang-Chi Chen, Robert Kates

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1999

Langue:

english

Fichier:

PDF, 2.15 MB

english, 1999

41

Regio- and stereoselective ring opening of epoxide with cyanoguanidine dianions, a facile synthesis of the KATP opener BMS-180448

Bang-Chi Chen, Sandra L Quinlan, J.Gregory Reid, Paul A Jass, Tonya P Robinson, William A Early, Edward J Delaney, Michael J Humora, Gary D Madding, John J Venit, William J Winter

Journal:

Tetrahedron: Asymmetry

Année:

1998

Langue:

english

Fichier:

PDF, 74 KB

english, 1998

42

Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase

William J. Pitts, Junqing Guo, T.G.Murali Dhar, Zhongqi Shen, Henry H. Gu, Scott H. Watterson, Mark S. Bednarz, Bang-Chi Chen, Joel C. Barrish, Donna Bassolino, Daniel Cheney, Catherine A. Fleener, Ka

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 149 KB

english, 2002

43

C-3 Amido-Indole cannabinoid receptor modulators

John Hynes Jr., Katerina Leftheris, Hong Wu, Chennagiri Pandit, Ping Chen, Derek J. Norris, Bang-Chi Chen, Rulin Zhao, Peter A. Kiener, Xiaorong Chen, Lori A. Turk, Vina Patil-Koota, Kathleen M. Gillo

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 126 KB

english, 2002

44

Oxidation of 1,3-dicarbonyl compounds using (camphorylsulfonyl)oxaziridines

Franklin A. Davis, Hu Liu, Bang-Chi Chen, Ping Zhou

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 636 KB

english, 1998

45

Enzymatic synthesis of l-6-hydroxynorleucine

Ronald L. Hanson, Mark D. Schwinden, Amit Banerjee, David B. Brzozowski, Bang-Chi Chen, Bharat P. Patel, Clyde G. McNamee, Gus A. Kodersha, David R. Kronenthal, Ramesh N. Patel, Laszlo J. Szarka

Journal:

Bioorganic & Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 189 KB

english, 1999

46

A facile and efficient synthesis of d3-labelled Reyataz™

Huiping Zhang, Samuel J. Bonacorsi Jr, Bang-Chi Chen, Leslie W. Leith, J. Kent Rinehart, Balu Balasubramanian, Joel C. Barrish

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2005

Langue:

english

Fichier:

PDF, 138 KB

english, 2005

47

ChemInform Abstract: AlMe3-Promoted Formation of Amides from Acids and Amines.

Jianqing Li, Krishnananthan Subramaniam, Daniel Smith, Jennifer X. Qiao, Jie Jack Li, Jingfang Qian-Cutrone, John F. Kadow, Gregory D. Vite, Bang-Chi Chen

Journal:

Année:

2012

Fichier:

PDF, 41 KB

2012

48

Synthesis of ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate via regioselective dipolar cycloaddition

Michael A. Schmidt, Kishta Katipally, Antonio Ramirez, Omid Soltani, Xiaoping Hou, Huiping Zhang, Bang-Chi Chen, Xinhua Qian, Rajendra P. Deshpande

Journal:

Tetrahedron Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2012

49

Synthesis of a Serinamide by Aminolysis of an N-Unsubstituted α-Amino Ester

Reid, J. Gregory, Chen, Bang-Chi, Njegovan, Joan F., Quinlan, Sandra L., Stark, Derron R., Reynolds, Ann-Marie, Pickup, Barry, Harrison, Brian

Journal:

Organic Process Research & Development

Année:

1997

Langue:

english

Fichier:

PDF, 72 KB

english, 1997

50

Meldrum's Acid in Orgnaic Synthesis

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 1.14 MB

english, 1991